A simple man, Dr. Walter Newman, has high aspirations to cure all disease through genetic manipulation. His obsession with his mission draws him deeper into his own dark world, distracting him from his wife Olivia and from his responsibilities to his patients at the Edgewood Asylum. The doctors loyal but diabolical nurse, Ms. Tinsley, decides to take matters into her own hands and in secret she conducts her own experiment. When Dr. Newman realizes what has been done, a deformed creature that defies nature is created. Part human, part nightmare. Dr. Newman knows what he must do, but is it already too late?

Growing up as identical twin sisters, Lora and Ashley Gerritson always had a special psychic bond. When one would feel pain, sorrow or happiness, the other felt it too. While Lora left the small town that haunted her as a child to become a successful photographer in the big city, her sister, Ashley, remained to live a simple life working at the local diner with her friend Maggie. Lora's life is suddenly changed when she begins to receive chilling visions from her sister, Ashley. Something is horribly wrong...she can feel it. Lora knows she must return to the small town of her childhood to find Ashley. She begins to realize that Barry Drake, a well-loved, upstanding member of the community, may hold the key to finding Ashley. There is something dark and unsettling about him. As the visions become stronger, she feels that time is running out. Prepare yourself for a game of cat and mouse that unfolds to reveal the mystery of a sister's "Second Coming".

The son of an eccentric detective steps into his father's shoes after his mother is wrongly arrested for stealing a baby panda.